Sub-regional volumes changes of the corpus callosum in the drug naive patients with late-onset depression.
Identifieur interne : 000302 ( Main/Exploration ); précédent : 000301; suivant : 000303Sub-regional volumes changes of the corpus callosum in the drug naive patients with late-onset depression.
Auteurs : Changtae Hahn [Corée du Sud] ; Hyun-Kook Lim [États-Unis] ; Wang Youn Won [Corée du Sud] ; Soo-Hyun Joo [Corée du Sud] ; Kook Jin Ahn [Corée du Sud] ; Won-Sang Jung [Corée du Sud] ; Chang Uk Lee [Corée du Sud]Source :
- Progress in neuro-psychopharmacology & biological psychiatry [ 1878-4216 ] ; 2015.
Descripteurs français
- KwdFr :
- Apprentissage verbal (physiologie), Corps calleux (anatomopathologie), Dépression (anatomopathologie), Dépression (physiopathologie), Femelle, Humains, Imagerie par résonance magnétique, Imagerie tridimensionnelle, Mâle, Mémoire (physiologie), Questionnaire sur l'état mental de Kahn, Statistique non paramétrique, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests neuropsychologiques, Études rétrospectives.
- MESH :
- anatomopathologie : Corps calleux, Dépression.
- physiologie : Apprentissage verbal, Mémoire.
- physiopathologie : Dépression.
- Femelle, Humains, Imagerie par résonance magnétique, Imagerie tridimensionnelle, Mâle, Questionnaire sur l'état mental de Kahn, Statistique non paramétrique, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests neuropsychologiques, Études rétrospectives.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Corpus Callosum (pathology), Depression (pathology), Depression (physiopathology), Female, Humans, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Memory (physiology), Mental Status Schedule, Neuropsychological Tests, Retrospective Studies, Statistics, Nonparametric, Verbal Learning (physiology).
- MESH :
- pathology : Corpus Callosum, Depression.
- physiology : Memory, Verbal Learning.
- physiopathology : Depression.
- Aged, Aged, 80 and over, Female, Humans, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Mental Status Schedule, Neuropsychological Tests, Retrospective Studies, Statistics, Nonparametric.
Abstract
Although sub-regional analysis methods of the corpus callosum (CC) have been developed, there has been no in vivo magnetic resonance imaging (MRI) study on a sub-regional volume analysis of the CC of late-onset depression (LOD). The aim of this study was to investigate the CC volume differences between LOD subjects and healthy elderly controls using a sub-regional analysis technique. Forty subjects with LOD and thirty nine group-matched healthy control subjects underwent 3T MRI scanning, and sub-regional volumes of the CC were measured and compared between the groups. The volumes of total (F=5.8, p=0.001), the anterior (F=5.2, p=0.001) and the posterior CC (F=5.1, p=0.001) were significantly reduced in the LOD group as compared to the control group. We measured cognitive functions in several different domains (language functions, verbal learning, visuospatial functions, delayed recall, memory consolidation, recognition memory, and executive functions) through the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease. The anterior CC volume in the LOD group showed significant positive correlation with the Verbal Fluency scores. The posterior CC volume in the LOD group was positively correlated significantly with the Word List Memory, the Word List Recall and the Constructional Praxis scores. This study is the first to elaborate the sub-regional volume differences of the CC between controls and LOD patients. These structural changes in the CC might be at the core of the underlying neurobiological mechanisms in LOD.
DOI: 10.1016/j.pnpbp.2014.07.008
PubMed: 25134843
Affiliations:
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Catholic Argo-Medical Center, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Psychiatry, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Republic of Korea; Catholic Argo-Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lim, Hyun Kook" sort="Lim, Hyun Kook" uniqKey="Lim H" first="Hyun-Kook" last="Lim">Hyun-Kook Lim</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, The Catholic University of Korea, St. Vincent's Hospital, Suwon, Republic of Korea; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, The Catholic University of Korea, St. Vincent's Hospital, Suwon, Republic of Korea; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Won, Wang Youn" sort="Won, Wang Youn" uniqKey="Won W" first="Wang Youn" last="Won">Wang Youn Won</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, The Catholic University of Korea, Uijeongbu St. Mary's Hospital, Uijeongbu, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Psychiatry, The Catholic University of Korea, Uijeongbu St. Mary's Hospital, Uijeongbu</wicri:regionArea><wicri:noRegion>Uijeongbu</wicri:noRegion></affiliation></author><author><name sortKey="Joo, Soo Hyun" sort="Joo, Soo Hyun" uniqKey="Joo S" first="Soo-Hyun" last="Joo">Soo-Hyun Joo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, The Catholic University of Korea, St. Vincent's Hospital, Suwon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Psychiatry, The Catholic University of Korea, St. Vincent's Hospital, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Ahn, Kook Jin" sort="Ahn, Kook Jin" uniqKey="Ahn K" first="Kook Jin" last="Ahn">Kook Jin Ahn</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiology, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Radiology, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jung, Won Sang" sort="Jung, Won Sang" uniqKey="Jung W" first="Won-Sang" last="Jung">Won-Sang Jung</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, The Catholic University of Korea, St. Vincent's Hospital, Suwon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Radiology, The Catholic University of Korea, St. Vincent's Hospital, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Chang Uk" sort="Lee, Chang Uk" uniqKey="Lee C" first="Chang Uk" last="Lee">Chang Uk Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Republic of Korea; Catholic Argo-Medical Center, Seoul, Republic of Korea. Electronic address: jihan@catholic.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Psychiatry, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Republic of Korea; Catholic Argo-Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Progress in neuro-psychopharmacology & biological psychiatry</title><idno type="eISSN">1878-4216</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Corpus Callosum (pathology)</term><term>Depression (pathology)</term><term>Depression (physiopathology)</term><term>Female</term><term>Humans</term><term>Imaging, Three-Dimensional</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Memory (physiology)</term><term>Mental Status Schedule</term><term>Neuropsychological Tests</term><term>Retrospective Studies</term><term>Statistics, Nonparametric</term><term>Verbal Learning (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Apprentissage verbal (physiologie)</term><term>Corps calleux (anatomopathologie)</term><term>Dépression (anatomopathologie)</term><term>Dépression (physiopathologie)</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Imagerie tridimensionnelle</term><term>Mâle</term><term>Mémoire (physiologie)</term><term>Questionnaire sur l'état mental de Kahn</term><term>Statistique non paramétrique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tests neuropsychologiques</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Corps calleux</term><term>Dépression</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Callosum</term><term>Depression</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Apprentissage verbal</term><term>Mémoire</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Memory</term><term>Verbal Learning</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Dépression</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Imaging, Three-Dimensional</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mental Status Schedule</term><term>Neuropsychological Tests</term><term>Retrospective Studies</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Imagerie tridimensionnelle</term><term>Mâle</term><term>Questionnaire sur l'état mental de Kahn</term><term>Statistique non paramétrique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tests neuropsychologiques</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although sub-regional analysis methods of the corpus callosum (CC) have been developed, there has been no in vivo magnetic resonance imaging (MRI) study on a sub-regional volume analysis of the CC of late-onset depression (LOD). The aim of this study was to investigate the CC volume differences between LOD subjects and healthy elderly controls using a sub-regional analysis technique. Forty subjects with LOD and thirty nine group-matched healthy control subjects underwent 3T MRI scanning, and sub-regional volumes of the CC were measured and compared between the groups. The volumes of total (F=5.8, p=0.001), the anterior (F=5.2, p=0.001) and the posterior CC (F=5.1, p=0.001) were significantly reduced in the LOD group as compared to the control group. We measured cognitive functions in several different domains (language functions, verbal learning, visuospatial functions, delayed recall, memory consolidation, recognition memory, and executive functions) through the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease. The anterior CC volume in the LOD group showed significant positive correlation with the Verbal Fluency scores. The posterior CC volume in the LOD group was positively correlated significantly with the Word List Memory, the Word List Recall and the Constructional Praxis scores. This study is the first to elaborate the sub-regional volume differences of the CC between controls and LOD patients. These structural changes in the CC might be at the core of the underlying neurobiological mechanisms in LOD.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>États-Unis</li></country><region><li>Pennsylvanie</li><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Hahn, Changtae" sort="Hahn, Changtae" uniqKey="Hahn C" first="Changtae" last="Hahn">Changtae Hahn</name></region><name sortKey="Ahn, Kook Jin" sort="Ahn, Kook Jin" uniqKey="Ahn K" first="Kook Jin" last="Ahn">Kook Jin Ahn</name><name sortKey="Joo, Soo Hyun" sort="Joo, Soo Hyun" uniqKey="Joo S" first="Soo-Hyun" last="Joo">Soo-Hyun Joo</name><name sortKey="Jung, Won Sang" sort="Jung, Won Sang" uniqKey="Jung W" first="Won-Sang" last="Jung">Won-Sang Jung</name><name sortKey="Lee, Chang Uk" sort="Lee, Chang Uk" uniqKey="Lee C" first="Chang Uk" last="Lee">Chang Uk Lee</name><name sortKey="Won, Wang Youn" sort="Won, Wang Youn" uniqKey="Won W" first="Wang Youn" last="Won">Wang Youn Won</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Lim, Hyun Kook" sort="Lim, Hyun Kook" uniqKey="Lim H" first="Hyun-Kook" last="Lim">Hyun-Kook Lim</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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